Modulation of TASK-like background potassium channels in rat arterial chemoreceptor cells by intracellular ATP and other nucleotides.

Journal article

The carotid body's physiological role is to sense arterial oxygen, CO(2) and pH. It is however, also powerfully excited by inhibitors of oxidative phosphorylation. This latter observation is the cornerstone of the mitochondrial hypothesis which proposes that oxygen is sensed through changes in energy metabolism. All of these stimuli act in a similar manner, i.e. by inhibiting a background TASK-like potassium channel (K(B)) they induce membrane depolarization and thus neurosecretion. In this s...

Expand abstract

Authors: Varas, R; Wyatt, C; Buckler, K

• Publication status: Published
• Journal: Journal of physiology
• Volume: 583
• Issue: Pt 2
• Pages: 521-536
• Publication date: 2007-09-01
• DOI: 10.1113/jphysiol.2007.135657
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Cyanides; Magnesium; Uncoupling Agents; Cell Hypoxia; Patch-Clamp Techniques; Potassium; Signal Transduction; Gerbillinae; Potassium Channels, Tandem Pore Domain; Membrane Potentials; Rotenone; Oxygen; Ion Channel Gating; Guanosine Triphosphate; Enzyme Inhibitors; Oxidative Phosphorylation; Uridine Triphosphate; Animals; Carotid Body; Rats; 2,4-Dinitrophenol; Oligomycins; Adenosine Triphosphate