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A role for human homologous recombination factors in suppressing microhomology-mediated end joining.

Abstract:

DNA double-strand breaks (DSBs) are toxic lesions, which if improperly repaired can result in cell death or genomic instability. DSB repair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) pathways. However, a mutagenic alternative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed. While MMEJ is suppressed by C-NHEJ, the relationship between HR and MMEJ is less clear. Here, we describe a role for HR genes...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkw326

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
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Funding agency for:
Ahrabi, S
Grant:
C5255/A15935
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Funding agency for:
Ahrabi, S
Grant:
C5255/A15935
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Funding agency for:
Sarkar, S
Grant:
MC PC 12003
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Funding agency for:
Pirovano, G
Grant:
C38302/A12981
More from this funder
Funding agency for:
Pirovano, G
Grant:
C38302/A12981
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Pages:
gkw326-gkw326
Publication date:
2016-01-01
Acceptance date:
2016-04-14
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Source identifiers:
619663
Language:
English
Pubs id:
pubs:619663
UUID:
uuid:4b1c7c4a-ed79-441d-9373-7720e468dfac
Local pid:
pubs:619663
Deposit date:
2016-05-26

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