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Immunogenicity and efficacy of a chimpanzee adenovirus-vectored Rift Valley fever vaccine in mice.

Abstract:

BACKGROUND: Rift Valley Fever (RVF) is a viral zoonosis that historically affects livestock production and human health in sub-Saharan Africa, though epizootics have also occurred in the Arabian Peninsula. Whilst an effective live-attenuated vaccine is available for livestock, there is currently no licensed human RVF vaccine. Replication-deficient chimpanzee adenovirus (ChAd) vectors are an ideal platform for development of a human RVF vaccine, given the low prevalence of neutralizing antibod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1743-422x-10-349

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
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More from this funder
Funding agency for:
Warimwe, G
Grant:
098635/B/12/Z
Publisher:
BioMed Central Publisher's website
Journal:
Virology journal Journal website
Volume:
10
Issue:
1
Pages:
349
Publication date:
2013-01-01
DOI:
EISSN:
1743-422X
ISSN:
1743-422X
Source identifiers:
441764

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