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Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers

Abstract:

β-Lactams are the most successful antibacterials, but their effectiveness is threatened by resistance, most importantly by production of serine- and metallo-β-lactamases (MBLs). MBLs are of increasing concern because they catalyse the hydrolysis of almost all β-lactam antibiotics, including recent generation carbapenems. Clinically useful serine-β-lactamase inhibitors have been developed, but such inhibitors are not available for MBLs. L-Captopril, used to treat hypertension via angiotensin-c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/AAC.01335-15

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
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Biotechnology and Biological Sciences Research Council More from this funder
Cancer Research UK More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Publication date:
2015-12-31
Acceptance date:
2015-10-03
DOI:
EISSN:
1098-6596
ISSN:
066-4804
Source identifiers:
571966
Pubs id:
pubs:571966
UUID:
uuid:4bab557f-d47e-4d91-9d38-01da6cdc7b8c
Local pid:
pubs:571966
Deposit date:
2015-12-03

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