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Journal article

Structural basis for plexin activation and regulation

Abstract:

Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization but extracellular regulation and activation mechanisms remain unclear. Here we present crystal structures of PlxnA (PlxnA1, PlxnA2 and PlxnA4) full ectodomains. Domains 1-9 form a ring-like conformation from which the C-terminal domain 10 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.neuron.2016.06.018

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Funding agency for:
Padilla-Parra, S
Cancer Research UK More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
Neuron Journal website
Publication date:
2016-07-07
Acceptance date:
2016-06-11
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Source identifiers:
627949
Keywords:
Pubs id:
pubs:627949
UUID:
uuid:4bb9fd9d-3b19-4d8e-8575-40f56182b6aa
Local pid:
pubs:627949
Deposit date:
2016-06-15

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