Restricted IgG1 subclass of anti-Yo antibodies in paraneoplastic cerebellar degeneration.

Journal article

Paraneoplastic cerebellar degeneration (PCD) occurs as a non-metastatic manifestation of cancer in a small proportion of patients with certain breast or gynaecological tumours, and is characterised by widespread Purkinje cell loss. Antibodies against a Purkinje cell cytoplasmic antigen, called Yo, that is expressed by the tumours, are present in the majority of these patients, but the pathogenic role of the antibodies is not clear. To characterise further the immune response in these cases, 1...

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Authors: Amyes, E; Curnow, J; Stark, Z; Corlett, L; Sutton, I

• Publication status: Published
• Journal: Journal of neuroimmunology
• Volume: 114
• Issue: 1-2
• Pages: 259-264
• Publication date: 2001-03-01
• DOI: 10.1016/s0165-5728(00)00445-8
• EISSN: 1872-8421
• ISSN: 0165-5728
• Language: English
• Keywords: Rats, Inbred Lew; Humans; Hu Paraneoplastic Encephalomyelitis Antigens; Immunoglobulin G; Cell Division; Paraneoplastic Cerebellar Degeneration; Neoplasm Proteins; Rats; Autoantigens; Interleukin-4; Autoantibodies; Nerve Tissue Proteins; DNA-Binding Proteins; Th2 Cells; RNA-Binding Proteins; Animals; Th1 Cells; Interferon-gamma