Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha.

Journal article

BACKGROUND: In patients with louse-borne relapsing fever (Borrelia recurrentis infection), antimicrobial treatment is often followed by sudden fever, rigors, and persistent hypotension (Jarisch-Herxheimer reactions) that are associated with increases in plasma concentrations of tumor necrosis factor alpha (TNF-alpha), interleukin-6, and interleukin-8. We attempted to determine whether sheep polyclonal Fab antibody fragments against TNF-alpha (anti-TNF-alpha Fab) could suppress the Jarisch-Her...

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Authors: Fekade, D; Knox, K; Hussein, K; Melka, A; Lalloo, D

• Publication status: Published
• Journal: New England journal of medicine
• Volume: 335
• Issue: 5
• Pages: 311-315
• Publication date: 1996-08-01
• DOI: 10.1056/nejm199608013350503
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: Sheep; Adolescent; Anti-Bacterial Agents; Double-Blind Method; Tumor Necrosis Factor-alpha; Interleukin-6; Interleukin-8; Immunoglobulin Fab Fragments; Middle Aged; Fever; Treatment Outcome; Animals; Penicillins; Male; Female; Humans; Adult; Relapsing Fever; Inflammation