Journal article
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
- Abstract:
-
The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the human angiotensin-converting enzyme 2 (ACE2) receptor as a prelude to viral entry into the cell. Using a naive llama single-domain antibody library and PCR-based maturation, we have produced two closely related nanobodies, H11-D4 and H11-H4, that bind RBD (KD of 39 and 12 nM, respectively)...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41594-020-0469-6
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Structural and Molecular Biology Journal website
- Volume:
- 27
- Pages:
- 846–854
- Place of publication:
- United States
- Publication date:
- 2020-07-13
- Acceptance date:
- 2020-06-26
- DOI:
- EISSN:
-
1545-9985
- ISSN:
-
1545-9993
- Pmid:
-
32661423
Item Description
- Language:
- English
- Pubs id:
-
1119067
- Local pid:
- pubs:1119067
- Deposit date:
- 2020-09-09
Terms of use
- Copyright holder:
- Huo et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s), under exclusive licence to Springer Nature America, Inc. 2020
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