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Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo.

Abstract:

We have developed polyelectrolyte gene delivery vectors that display good extracellular stability and are activated intracellularly to permit transgene expression. The strategy comprises covalent crosslinking of primary amines in poly-L-lysine/DNA complexes with a crosslinking agent that can later be cleaved by reduction. Crosslinked complexes maintained the same size and surface charge but showed increased stability against polyelectrolyte exchange with poly-L-aspartic acid. Surface modifica...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/sj.gt.3301446

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Department of Engineering Science
Oxford college:
St Cross College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Publisher:
Springer Nature Publisher's website
Journal:
Gene Therapy Journal website
Volume:
8
Issue:
9
Pages:
713-724
Publication date:
2001-06-12
Acceptance date:
2001-02-14
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
Source identifiers:
397120

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