Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium.

Journal article

Within 6 h, shear stress upregulated intercellular adhesion molecule-1 (ICAM-1) (two- to four-fold, P<0.001) and induced matrix metalloproteinase-2 (MMP-2) in cultured human saphenous vein endothelial cells. By 8 h endothelial ICAM-1 levels returned to baseline, with concomitant increase in soluble ICAM-1 (sICAM-1) (P<0.001) and MMP-9 had been induced. Inclusion of a hydroxamate metalloproteinase inhibitor partially reversed the effects on ICAM-1 and sICAM-1 at 8 h, whereas TIMP-1, -2 o...

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Authors: Sultan, S; Gosling, M; Nagase, H; Powell, J

• Publication status: Published
• Journal: FEBS letters
• Volume: 564
• Issue: 1-2
• Pages: 161-165
• Publication date: 2004-04-01
• DOI: 10.1016/s0014-5793(04)00337-0
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: Matrix Metalloproteinase 2; Humans; Intercellular Adhesion Molecule-1; Stress, Mechanical; Enzyme Induction; Protein Processing, Post-Translational; Matrix Metalloproteinase 9; Saphenous Vein; Solubility; Up-Regulation; Protein Binding; Endothelium, Vascular