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Multitasking roles of the mammalian deacetylase SIRT6

Abstract:

Sirtuins (SIRT) are highly conserved proteins first described as nicotinamide adenine dinucleotide (NAD+)-dependent type III histone deacetylases. They are the mammalian homologs of the SIR2 gene found in yeast. Seven homologs (SIRT1–7) have been described, all sharing an NAD+ binding catalytic domain comprising 275 amino acids and variable N and C termini. This difference in their terminal domains dictates distant roles and cellular localization of the members of the sirtuin family. In this ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Oxford college:
University College
Role:
Author

Contributors

Role:
Editor
Role:
Editor
Role:
Editor
Publisher:
Academic Press Publisher's website
Pages:
117-130
Host title:
Introductory Review on Sirtuins in Biology, Aging, and Disease
Chapter number:
9
Publication date:
2018-04-27
DOI:
EISBN:
9780128135006
ISBN:
9780128134993
Language:
English
Keywords:
Subtype:
Chapter
Pubs id:
1182063
Local pid:
pubs:1182063
Deposit date:
2021-06-15

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