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Chronic activation of γ2 AMPK induces obesity and reduces β cell function

Abstract:

Despite significant advances in our understanding of the biology determining systemic energy homeostasis, the treatment of obesity remains a medical challenge. Activation of AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for the treatment of obesity and its complications. AMPK is a conserved, ubiquitously expressed, heterotrimeric serine/threonine kinase whose short-term activation has multiple beneficial metabolic effects. Whether these translate into long-te...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cmet.2016.04.003

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Strategic
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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More from this funder
Funding agency for:
Yavari, A
Grant:
Research Training Fellowship (086632/Z/08/Z
More from this funder
Funding agency for:
Yavari, A
Grant:
Research Training Fellowship (086632/Z/08/Z
More from this funder
Funding agency for:
Yavari, A
Grant:
Research Training Fellowship (086632/Z/08/Z
More from this funder
Funding agency for:
Watkins, H
Grant:
MR/K019023/1
More from this funder
Funding agency for:
Watkins, H
Grant:
MR/K019023/1
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Publisher:
Cell Press Publisher's website
Journal:
Cell Metabolism Journal website
Publication date:
2016-04-28
Acceptance date:
2016-04-01
DOI:
EISSN:
1932-7420
ISSN:
1550-4131
Source identifiers:
616409
Pubs id:
pubs:616409
UUID:
uuid:4c6a4682-da59-4812-89f8-36449b4fb3d5
Local pid:
pubs:616409
Deposit date:
2016-04-19

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