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5-HT2C receptor perturbation has bidirectional influence over instrumental vigour and restraint

Abstract:

The serotonin (5-HT) system, particularly the 5-HT2C receptor, has consistently been implicated in behavioural control. However, while some studies have focused on the role 5-HT2C receptors play in regulating motivation to work for reward, others have highlighted its importance in response restraint. To date, it is unclear how 5-HT transmission at this receptor regulates the balance of response invigoration and restraint in anticipation of future reward. In addition, it remains to be establis...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00213-021-05992-8

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
ORCID:
0000-0003-2635-5638
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Oxford college:
New College
Role:
Author
ORCID:
0000-0002-6850-9255
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
ORCID:
0000-0003-0117-2894
Publisher:
Springer Publisher's website
Journal:
Psychopharmacology Journal website
Volume:
239
Issue:
1
Pages:
123–140
Publication date:
2021-11-11
Acceptance date:
2021-09-20
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Language:
English
Keywords:
Pubs id:
1150020
Local pid:
pubs:1150020
Deposit date:
2021-09-20

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