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Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina

Abstract:

Adeno-associated viral vectors (AAV) have been shown to be safe in the treatment of retinal degenerations in clinical trials. Thus, improving the efficiency of viral gene delivery has become increasingly important to increase the success of clinical trials. In this study, structural domains of different rAAV serotypes isolated from primate brain were combined to create novel hybrid recombinant AAV serotypes, rAAV2/rec2 and rAAV2/rec3. The efficacy of these novel serotypes were assessed in wil...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0060361

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
4
Pages:
ARTN e60361
Publication date:
2013-04-09
Acceptance date:
2013-02-26
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
395943
Language:
English
Keywords:
Pubs id:
pubs:395943
UUID:
uuid:4ce63ee9-7324-4257-bdae-99ed95fcc38e
Local pid:
pubs:395943
Deposit date:
2013-11-16

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