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Caspase-dependent activation of Hedgehog-signalling sustains proliferation and differentiation of ovarian somatic stem cells

Abstract:

There is increasing evidence associating the role of caspases with the regulation of basic cellular functions beyond apoptosis. However, the molecular interplay between these enzymes and the signalling networks active in non-apoptotic cellular scenarios remains largely uncharacterized. Here, we show that transient and non-apoptotic caspase activation facilitates Hedgehog-signalling in Drosophila and human ovarian cells with a somatic origin. Importantly, this novel caspase function controls g...

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Publication status:
Not published
Peer review status:
Not peer reviewed

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Publisher copy:
10.1101/722330

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-8663-3794
Cancer Research UK More from this funder
John Fell Fund More from this funder
Publisher:
Cold Spring Harbor Laboratory Publisher's website
Journal:
Biorxiv Journal website
Article number:
722330
Place of publication:
United Kingdom
Publication date:
2019-08-01
DOI:
Language:
English
Pubs id:
1109902
Local pid:
pubs:1109902
Deposit date:
2020-06-07

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