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[Effect of mutation Arg9lGly on the thermal stability of beta-tropomyosin]

Abstract:

The mutation Arg91Gly (R91G) in beta-tropomyosin (beta-TM) is known to cause distal arthrogryposis, a severe congenital disorder of muscle tissues. To elucidate how this mutation affects the structural properties of beta-TM, the thermal unfolding of beta-TM carrying mutation Arg91Gly was compared with that of the wild type protein. It was shown by differential scanning calorimetry and circular dichroism that this point mutation dramatically decreases the thermal stability of a significant par...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Journal:
Biofizika
Volume:
53
Issue:
6
Pages:
917-921
Publication date:
2008-01-01
ISSN:
0006-3029
Source identifiers:
105227
Language:
Russian
Keywords:
Pubs id:
pubs:105227
UUID:
uuid:4d274462-fd7c-44f2-8283-7ecc835b36f3
Local pid:
pubs:105227
Deposit date:
2012-12-19

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