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Sca-1+ progenitors derived from embryonic stem cells differentiate into endothelial cells capable of vascular repair after arterial injury.

Abstract:

BACKGROUND: Embryonic stem cells possess the ability to differentiate into endothelium. The ability to produce large volumes of endothelium from embryonic stem cells could provide a potential therapeutic modality for vascular injury. We describe an approach that selects endothelial cells using magnetic beads that may be used therapeutically to treat arterial injury. METHODS AND RESULTS: Large numbers of endothelial cells (ECs) with high purity were produced using Sca-1+ cells isolated with m...

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Publication status:
Published

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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
26
Issue:
10
Pages:
2244-2251
Publication date:
2006-10-01
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
104909

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