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Thesis

Analysis of mouse models of insulin secretion disorders

Abstract:

In this thesis, three mouse models and cell culture techniques were used to investigate genetic factors leading to glucose intolerance, diabetes or hyperinsulinemia.

  1. Loss of nicotinamide nucleotide transhydrogenase (Nnt) function is linked to ROS-mediated uncoupling of mitochondrial metabolism and reduced insulin secretion. The enzymatic activity of Nnt generates mitochondrial NADPH essential for ROS detoxification. However, the exact nature of ROS as well as the ant...
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Professor Frances Ashcroft
Oxford college:
Wolfson College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Kaizik, S
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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