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Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome

Abstract:

Elucidating the mechanisms of mutation accumulation and fixation is critical to understand the nature of genetic variation and its contribution to genome evolution. Of particular interest is the effect of insertions and deletions (indels) on the evolution of genome landscapes. Recent population-scaled sequencing efforts provide unprecedented data for analyzing the relative impact of selection versus nonadaptive forces operating on indels. Here, we combined McDonald–Kreitman tests with the ana...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/molbev/mst185

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
Université Lyon
Role:
Author

Contributors

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Funding agency for:
Kvikstad, E
Grant:
ALTF 354-2010
More from this funder
Funding agency for:
Duret, L
Grant:
ABS4NGS: ANR-11-BINF-0001-06
Publisher:
Oxford University Press Publisher's website
Journal:
Molecular Biology and Evolution Journal website
Volume:
31
Issue:
1
Pages:
23–36
Publication date:
2013-10-01
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
Language:
English
Keywords:
Subjects:
UUID:
uuid:4d515e61-bce9-4a78-ac80-45234c853fb9
Local pid:
ora:8057
Deposit date:
2014-02-24

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