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A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer

Abstract:
Background miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 on DNA damage, and its potential as a therapeutic agent.
Methods RNA-IP, RNA-seq, RNA-ISH, DNA fibre assays, in vivo xenograft studies and bioinformatics approaches were used alongside a novel method for amplification-free, single nucl... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12943-022-01540-w

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Publisher:
BioMed Central Publisher's website
Journal:
Molecular Cancer Journal website
Volume:
21
Issue:
1
Article number:
82
Publication date:
2022-03-22
Acceptance date:
2022-02-10
DOI:
EISSN:
1476-4598
Language:
English
Keywords:
Pubs id:
1246840
Local pid:
pubs:1246840
Deposit date:
2022-03-22

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