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Unlocking the secrets of the regenerating fish heart: comparing regenerative models to shed light on successful regeneration

Abstract:

The adult human heart cannot repair itself after injury and, instead, forms a permanent fibrotic scar that impairs cardiac function and can lead to incurable heart failure. The zebrafish, amongst other organisms, has been extensively studied for its innate capacity to repair its heart after injury. Understanding the signals that govern successful regeneration in models such as the zebrafish will lead to the development of effective therapies that can stimulate endogenous repair in humans. To ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3390/jcdd8010004

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0001-6624-3038
Publisher:
MDPI Publisher's website
Journal:
Journal of Cardiovascular Development and Disease Journal website
Volume:
8
Issue:
1
Article number:
4
Publication date:
2021-01-16
Acceptance date:
2021-01-12
DOI:
EISSN:
2308-3425
Language:
English
Keywords:
Pubs id:
1157499
Local pid:
pubs:1157499
Deposit date:
2021-01-20

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