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MEF2 transcription factors are key regulators of sprouting angiogenesis

Abstract:

Angiogenesis, the fundamental process by which new blood vessels form from existing ones, depends on precise spatial and temporal gene expression within specific compartments of the endothelium. However, the molecular links between pro-angiogenic signals and downstream gene expression remain unclear. During sprouting angiogenesis, the specification of endothelial cells into the tip cells that lead new blood vessel sprouts is coordinated by VEGFA and Dll4/Notch signaling, and requires high lev...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/gad.290619.116

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Funding agency for:
Sacilotto, N
Grant:
PG/10/83/28610
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Funding agency for:
Sacilotto, N
Grant:
PG/10/83/28610
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Funding agency for:
Payne, S
Grant:
PG/16/34/32135
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Funding agency for:
Liu, K
Grant:
MR/J007765/1
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Funding agency for:
Biggs, D
Grant:
090532/Z/09/Z
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Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Genes and Development Journal website
Volume:
30
Pages:
2297-2309
Publication date:
2016-01-01
Acceptance date:
2016-09-29
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
Source identifiers:
648331
Keywords:
Pubs id:
pubs:648331
UUID:
uuid:4dfdbb0d-4a9e-4518-bc0d-60e5a4405764
Local pid:
pubs:648331
Deposit date:
2016-10-07

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