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Journal article

Bee venom processes human skin lipids for presentation by CD1a.

Abstract:

Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms contain CD1-presented antigens. Here, we show that venoms activate human T cells via CD1a proteins. Whereas CD1 proteins typically present lipids, chromatographic separation of venoms unexpectedly showed that stimulatory factors partition into protein-containing fractions. Thi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20141505

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Funding agency for:
Cerundolo, V
Grant:
C399/A2291
Medical Research Council More from this funder
Burroughs Wellcome Foundation Program in Translational Medicine More from this funder
National Institute for Health Research More from this funder
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
212
Issue:
2
Pages:
149-163
Publication date:
2015-02-01
Acceptance date:
2014-12-11
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
503480
Language:
English
Keywords:
Pubs id:
pubs:503480
UUID:
uuid:4e0893a0-353f-4e1e-844c-140c23f900d4
Local pid:
pubs:503480
Deposit date:
2016-03-30

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