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Effect of Modified Vaccinia Ankara–5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial

Abstract:

Importance:The success of immunotherapy with checkpoint inhibitors is not replicated in most cases of colorectal cancer; therefore, different strategies are urgently required. The oncofetal antigen 5T4 is expressed in more than 90% of cases of metastatic colorectal cancer (mCRC). Preliminary data using modified vaccinia Ankara-5T4 (MVA-5T4) in mCRC demonstrated that it safely induced serologic and T-cell responses. Objective:To determine whether antitumor immunity in mCRC could be increased u...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1001/jamaoncol.2017.2579

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Role:
Author
ORCID:
0000-0002-4120-0688
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Role:
Author
ORCID:
0000-0002-2600-2034
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Publisher:
American Medical Association Publisher's website
Journal:
JAMA Oncology Journal website
Volume:
3
Issue:
10
Article number:
e172579
Publication date:
2017-09-07
Acceptance date:
2017-06-14
DOI:
ISSN:
2374-2445 and 2374-2437
Pmid:
28880972
Source identifiers:
729955
Language:
English
Keywords:
Pubs id:
pubs:729955
UUID:
uuid:4e25dcbf-3802-4281-a517-b76e7c16350d
Local pid:
pubs:729955
Deposit date:
2019-02-27

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