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Journal article : Review

Treatment and prevention of lipoprotein(a)-mediated cardiovascular disease: the emerging potential of RNA interference therapeutics

Abstract:

Lipid- and lipoprotein-modifying therapies have expanded substantially in the last 25 years, resulting in reduction in the incidence of major adverse cardiovascular events. However, no specific lipoprotein(a) [Lp(a)]-targeting therapy has yet been shown to reduce cardiovascular disease risk. Many epidemiological and genetic studies have demonstrated that Lp(a) is an important genetically determined causal risk factor for coronary heart disease, aortic valve disease, stroke, heart failure, and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvab100

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular Research Journal website
Volume:
118
Issue:
5
Pages:
1218–1231
Publication date:
2021-03-26
Acceptance date:
2021-03-24
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1169997
Local pid:
pubs:1169997
Deposit date:
2021-04-01

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