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Interferometric scattering microscopy for the study of molecular motors

Abstract:

Our understanding of molecular motor function has been greatly improved by the development of imaging modalities, which enable real-time observation of their motion at the single-molecule level. Here, we describe the use of a new method, interferometric scattering microscopy, for the investigation of motor protein dynamics by attaching and tracking the motion of metallic nanoparticle labels as small as 20 nm diameter. Using myosin-5, kinesin-1, and dynein as examples, we describe the basic as...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/bs.mie.2016.08.016

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
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Funding agency for:
Andrecka, J
Grant:
330215
Publisher:
Elsevier Publisher's website
Volume:
581
Pages:
517-539
Series:
Methods in Enzymology
Host title:
Methods in Enzymology
Publication date:
2016-10-10
DOI:
EISSN:
1557-7988
ISSN:
0076-6879
Source identifiers:
656801
ISBN:
9780128092675
Language:
English
Keywords:
Pubs id:
pubs:656801
UUID:
uuid:4e7b2e2e-ff46-4c41-a10c-f482511c3cf1
Local pid:
pubs:656801
Deposit date:
2016-11-22

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