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No association of coronary artery disease with x-chromosomal variants in comprehensive international meta-analysis

Abstract:

In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have only one. Also, one of the female X chromosomes may be inactivated. Therefore, special test statistics and quality control procedures are required. Thus, little is known about the r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep35278

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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
35278
Publication date:
2016-10-12
Acceptance date:
2016-09-26
DOI:
ISSN:
2045-2322
Source identifiers:
652915
Language:
English
Keywords:
Pubs id:
pubs:652915
UUID:
uuid:4eabe6c4-3674-4cf4-b9cc-967e68f2d071
Local pid:
pubs:652915
Deposit date:
2016-12-01

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