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Journal article

Technique of retinal gene therapy: delivery of viral vector into the subretinal space

Abstract:

PurposeSafe and reproducible delivery of gene therapy vector into the subretinal space is essential for successful targeting of the retinal pigment epithelium (RPE) and photoreceptors. The success of surgery is critical for the clinical efficacy of retinal gene therapy. Iatrogenic detachment of the degenerate (often adherent) retina in patients with hereditary retinal degenerations and small volume (eg, 0.1 ml) subretinal injections pose new surgical challenges.MethodsOur subretinal gene ther...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/eye.2017.158

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences; Biomedical Research Centre
Oxford college:
Merton College
Role:
Author
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Funding agency for:
MacLaren, R
Choroideremia Research Foundation More from this funder
Fight for Sight More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Eye Journal website
Volume:
31
Issue:
9
Pages:
1308-1316
Publication date:
2017-08-18
Acceptance date:
2017-07-03
DOI:
EISSN:
1476-5454
ISSN:
0950-222X
Pmid:
28820183
Source identifiers:
722789
Language:
English
Pubs id:
pubs:722789
UUID:
uuid:4ed631f5-82bc-487f-9d35-e233201412db
Local pid:
pubs:722789
Deposit date:
2017-11-06

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