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Mature, long-lived CD4+ and CD8+ T cells are generated by the thymoma in myasthenia gravis.

Abstract:

Antibodies to muscle acetylcholine receptors, to other muscle antigens, and to some cytokines are found in the majority of patients with thymic tumors (thymomas) and myasthenia gravis (MG). The role of the tumor in initiating autoimmunity, however, is unclear; in particular, it is not known whether the thymoma exports mature and long-lived T cells, which could provide help for antibody production in the periphery. Here, we quantified recently exported thymic T cells using the approach of meas...

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Publication status:
Published

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Publisher copy:
10.1002/ana.1017

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Annals of neurology
Volume:
50
Issue:
1
Pages:
64-72
Publication date:
2001-07-01
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Source identifiers:
241796
Language:
English
Keywords:
Pubs id:
pubs:241796
UUID:
uuid:4f38bbeb-0650-4ddd-9315-2506b4866a94
Local pid:
pubs:241796
Deposit date:
2012-12-19

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