Journal article
Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1
- Abstract:
-
Cell-cell junctions are an integral part of epithelia and are often disrupted in cancer cells during epithelial-to-mesenchymal transition (EMT), which is a main driver of metastatic spread. We show here that Metastasis suppressor-1 (Mtss1; Missing in Metastasis, MIM), a member of the IMD-family of proteins, inhibits cell-cell junction disassembly in wound healing or HGF-induced scatter assays by enhancing cell-cell junction strength. Mtss1 not only makes cells more resistant to cell-cell junc...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Cancer Research UK
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Medical Research Council
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 7
- Issue:
- 3
- Pages:
- e31141
- Publication date:
- 2012-03-27
- Acceptance date:
- 2012-01-03
- DOI:
- EISSN:
-
1932-6203
- Pmid:
-
22479308
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:632590
- UUID:
-
uuid:4f7c69a3-ca2a-44d4-aeae-c8764aa37cdb
- Local pid:
- pubs:632590
- Source identifiers:
-
632590
- Deposit date:
- 2016-12-07
Terms of use
- Copyright holder:
- Dawson et al
- Copyright date:
- 2012
- Notes:
- © 2012 Dawson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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