Journal article icon

Journal article

Ag-catalyzed insertion of alkynyl carbenes into C-C bonds of β-ketocarbonyls: a formal C(sp2) insertion

Abstract:

Here we report a silver-catalyzed alkynyl carbene insertion into β-ketocarbonyls using alkynyl N-nosylhydrazones as alkynyl carbene precursors, which provides access to trisubstituted allenyl ketones. This reaction represents the first example of an alkynyl carbene insertion into a C–C σ bond, affording products homologated with an sp2 carbon center. The products are useful substrates for further transformations. Experimental investigations and theoretical calculations suggest t...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Publisher copy:
10.1021/acs.orglett.1c04081

Authors


More by this author
Role:
Author
ORCID:
0000-0001-8791-6254
More by this author
Role:
Author
ORCID:
0000-0003-2225-0054
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Jesus College
Role:
Author
ORCID:
0000-0002-4149-0494
Expand authors...
Department of Science and Technology of Jilin Province More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
Organic Letters Journal website
Volume:
24
Issue:
2
Pages:
631-636
Publication date:
2022-01-05
Acceptance date:
2022-01-05
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Pmid:
34985288
Language:
English
Keywords:
Pubs id:
1232538
Local pid:
pubs:1232538
Deposit date:
2022-01-24

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP