Journal article
The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity.
- Abstract:
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The matrix (M) protein of wild isolates of rabies virus such as Tha (M-Tha) was previously shown to be able to interact with RelAp43, a protein of the NF-κB family, and to efficiently suppress NF-κB-dependent reporter gene expression, in contrast with the vaccine strain SAD. Here, we analyze the mechanisms involved in RelAp43-M protein interaction. We demonstrate that the central part of M-Tha, and the specific C-terminal region of RelAp43 are required for this interaction. Four differences i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1038/srep39420
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 6
- Pages:
- 39420
- Publication date:
- 2016-12-21
- Acceptance date:
- 2016-11-22
- DOI:
- ISSN:
-
2045-2322
- Source identifiers:
-
667796
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:667796
- UUID:
-
uuid:4fa3c6d0-0829-448a-9889-4bbb24beb209
- Local pid:
- pubs:667796
- Deposit date:
- 2017-01-10
Terms of use
- Copyright holder:
- Grimes et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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