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Journal article

Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice.

Abstract:

BACKGROUND: Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination. This has been achieved by removing the SC by abrasion or scarification or by delivering the vaccine intradermally (ID) with traditional needle-and-syringes or with long microneedle devices. Microneedle patch-based transdermal vaccine studies have predominantly focused on antibod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0022442

Authors


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Institution:
University of Oxford
Role:
Author
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Science Foundation Ireland More from this funder
Enterprise Ireland More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
7
Article number:
e22442
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
170213
Language:
English
Keywords:
Pubs id:
pubs:170213
UUID:
uuid:4fbb6f34-f328-4c08-b233-95e0871fe831
Local pid:
pubs:170213
Deposit date:
2012-12-19

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