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miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration

Abstract:

Circulating endothelial colony forming cells (ECFCs) contribute to vascular repair where they are a target for therapy. Since ECFC proliferative potential is increased in cord versus peripheral blood and to define regulatory factors controlling this proliferation, we compared the miRNA profiles of cord blood and peripheral blood ECFC-derived cells. Of the top 25 differentially regulated miRNAs selected, 22 were more highly expressed in peripheral blood ECFC-derived cells. After validating can...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep44137

Authors


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Funding agency for:
Harris, A
National Health Service More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
44137
Publication date:
2017-03-09
Acceptance date:
2017-02-02
DOI:
ISSN:
2045-2322
Source identifiers:
685271
Pubs id:
pubs:685271
UUID:
uuid:4fdf9eac-1813-42f5-8678-7d9447bd8b4d
Local pid:
pubs:685271
Deposit date:
2017-03-11

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