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The evolution of antibiotic resistance in a structured host population

Abstract:

The evolution of antibiotic resistance in opportunistic pathogens such as Streptococcus pneumoniae, Escherichia coli or Staphylococcus aureus is a major public health problem, as infection with resistant strains leads to prolonged hospital stay and increased risk of death. Here, we develop a new model of the evolution of antibiotic resistance in a commensal bacterial population adapting to a heterogeneous host population composed of untreated and treated hosts, and structured in different hos...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsif.2018.0040

Authors


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Role:
Author
ORCID:
0000-0003-0591-2466
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
BDI-NDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0003-2399-9657
Li Ka Shing Foundation More from this funder
Publisher:
Royal Society Publisher's website
Journal:
Journal of the Royal Society, Interface Journal website
Volume:
15
Issue:
143
Pages:
20180040
Publication date:
2018-06-30
Acceptance date:
2018-05-29
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Pmid:
29925579
Source identifiers:
860032
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:860032
UUID:
uuid:4fe14176-e242-4ac2-ba21-0e462fbc25ea
Local pid:
pubs:860032
Deposit date:
2018-09-11

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