Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.

Journal article

We studied the transmission-blocking effect of isonicotinic acid hydrazide (INH), a widely used anti-tuberculosis drug, against Plasmodium gallinaceum and Plasmodium berghei. INH-treatment of infected animals did not inhibit parasite development in the blood of the vertebrate host, but did inhibit exflagellation, ookinete formation, and oocyst development in the mosquito. Oocyst development was inhibited in a dose-dependent manner. The ED(50) in the P. gallinaceum/chicken/Aedes aegypti model ...

Expand abstract

Authors: Arai, M; Alavi, Y; Mendoza, J; Billker, O; Sinden, R

• Journal: Experimental parasitology
• Volume: 106
• Issue: 1-2
• Pages: 30-36
• Publication date: 2004-01-01
• DOI: 10.1016/j.exppara.2004.01.002
• EISSN: 1090-2449
• ISSN: 0014-4894
• Language: English
• Keywords: Dose-Response Relationship, Drug; Female; Insect Vectors; Isoniazid; Antitubercular Agents; Parasitemia; Aedes; Mice; Plasmodium gallinaceum; Chickens; Malaria; Plasmodium berghei; Animals; Antimalarials