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Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair

Abstract:

Notch has a well-defined role in controlling cell fate decisions in the embryo and the adult epidermis and immune systems, yet emerging evidence suggests Notch also directs non-cell-autonomous signalling in adult tissues. Here, we show that Notch1 works as a damage response signal. Epidermal Notch induces recruitment of immune cell subsets including RORγ+ ILC3s into wounded dermis; RORγ+ ILC3s are potent sources of IL17F in wounds and control immunological and epidermal cell responses. Mice d...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms11394

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Role:
Author
ORCID:
0000-0002-0583-1116
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Role:
Author
ORCID:
0000-0002-3242-1593
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Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Issue:
1
Pages:
ARTN 11394
Publication date:
2016-04-21
Acceptance date:
2016-03-21
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
27099134
Source identifiers:
727910
Language:
English
Keywords:
Pubs id:
pubs:727910
UUID:
uuid:50185503-91b7-4db4-bded-946aee79689c
Local pid:
pubs:727910
Deposit date:
2019-10-31

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