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Tetrahydrobiopterin and nitric oxide synthase recouplers

Abstract:

Generation of nitric oxide (NO) by the nitric oxide synthase (NOS) enzymes plays multiple signalling roles in every organ system, with crucial roles in the cardiovascular system, mediated by endothelial nitric oxide synthase (eNOS, encoded by NOS3) and neuronal nitric oxide synthase (nNOS, encoded by NOS1) in regulation of blood pressure, flow, oxygen delivery and cardiac function. Loss of normal NO-mediated functions in cardiovascular disease state is associated with changes in nitroso-redox...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/164_2020_390

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Strategic
Oxford college:
Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; Exeter College; EXETER COLLEGE
Role:
Author
ORCID:
0000-0002-1043-4342
Publisher:
Springer, Cham Publisher's website
Journal:
Handbook of experimental pharmacology Journal website
Pages:
339-352
Place of publication:
Germany
Publication date:
2020-11-03
DOI:
EISSN:
1865-0325
ISSN:
0171-2004
Pmid:
33140223
Language:
English
Keywords:
Pubs id:
1141179
Local pid:
pubs:1141179
Deposit date:
2020-11-30

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