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Thesis

Investigation of the effects of IGF-1 receptor blockade on chemoresistance of advanced melanoma

Abstract:

Advanced melanoma poses a major therapeutic challenge, and despite the development of recent promising therapeutic agents, resistance to treatment remains a problem. Until recently, despite low response rates, alkylating agents dacarbazine and temozolomide (TMZ) were the standard of care for the treatment of advanced melanoma. The cytotoxic effects of these agents relies upon the formation of alkylated base lesions such as O6-methylguanine (O6MeG), which is repaired b...

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Institution:
University of Oxford
Oxford college:
Exeter College
Role:
Author
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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Role:
Supervisor
Division:
MSD
Department:
Oncology
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:50578edf-5730-42ce-8305-0d52ff61538a
Local pid:
ora:10351
Deposit date:
2015-03-03

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