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Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF

Abstract:

Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1α and HIF-2α in the multi-nucleated, osteoclast-like giant cells and the mononuclear stromal component of giant cell tumour of bone (GCTB), a locally osteolytic primary bone tumour. HIF induction was observ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.2319

Authors


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Institution:
University of Oxford
Research group:
Botnar Research Centre
Department:
Medical Sciences Division - Orthopaedic Surgery
Role:
Researcher, Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Orthopaedic Surgery
Role:
Principal Investigator (PI), Author

Contributors

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Funding agency for:
Knowles, H
Grant:
LSHCCT-2006-018814
Publisher:
John Wiley & Sons, Ltd. Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
215
Issue:
1
Pages:
56-66
Publication date:
2008-05-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Language:
English
Keywords:
Subjects:
UUID:
uuid:5094045f-b17f-453d-b9ab-c43f21ffdbd7
Local pid:
ora:2534
Deposit date:
2009-01-23

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