Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3 (TIMP-3)
Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available. Attempts to treat the disease with small molecule inhibitors of the metalloproteinases that degrade the cartilage matrix have been hampered by a lack of specificity. We aimed to inhibit cartilage degradation by augmenting levels of the endogenous metalloproteinase inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP-3), through blocking its interaction with the endocytic sc...Expand abstract
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- Peer review status:
- Peer reviewed
- Copyright holder:
- Chanalaris et al
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Copyright © 2017 by The Authors.
This is an open access article distributed under the CC BY Attribution 4.0 International license.
- CC Attribution (CC BY)
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