Thesis
Defective iron homeostasis in lysosomal storage diseases
- Abstract:
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Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder characterized by the accumulation of multiple lipids in the late endosome/lysosomal system and reduced acidic store calcium levels. Since the lysosomal system is involved in regulating aspects of transition metal ion homeostasis and its intracellular compartmentalization, we have investigated whether there are metal ion metabolism defects and haematological abnormalities in NPC1 disease. We have identifie...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:5127c241-be64-4990-bef5-70e15d391394
- Local pid:
- ora:12027
- Deposit date:
- 2015-07-29
Terms of use
- Copyright holder:
- Chun-Wu Chen
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available via ORA.
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