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Thesis

Defective iron homeostasis in lysosomal storage diseases

Abstract:

Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder characterized by the accumulation of multiple lipids in the late endosome/lysosomal system and reduced acidic store calcium levels. Since the lysosomal system is involved in regulating aspects of transition metal ion homeostasis and its intracellular compartmentalization, we have investigated whether there are metal ion metabolism defects and haematological abnormalities in NPC1 disease. We have identifie...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Balliol College
Role:
Author
More by this author
Division:
MSD
Department:
Pharmacology
Role:
Author

Contributors

Division:
MSD
Department:
Pharmacology
Role:
Supervisor
More from this funder
Funding agency for:
Chen, C
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5127c241-be64-4990-bef5-70e15d391394
Local pid:
ora:12027
Deposit date:
2015-07-29

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