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Journal article

Electrophysiological and proarrhythmic effects of hydroxychloroquine challenge in guinea-pig hearts

Abstract:

Hydroxychloroquine (HCQ), clinically established in antimalarial and autoimmune therapy, recently raised cardiac arrhythmogenic concerns when used alone or with azithromycin (HCQ+AZM) in Covid-19. We report complementary, experimental, studies of its electrophysiological effects. In patch clamped HEK293 cells expressing human cardiac ion channels, HCQ inhibited IKr and IK1 at a therapeutic concentrations (IC50s: 10 ± 0....

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acsptsci.1c00166

Authors


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Kaifeng Excellent Key Laboratory Grant More from this funder
More from this funder
Grant:
PG/14/80/31106
PG/16/67/32340
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Pharmacology and Translational Science Journal website
Volume:
4
Issue:
5
Pages:
1639-1653
Publication date:
2021-08-30
DOI:
EISSN:
2575-9108
ISSN:
2575-9108
Pmid:
34661080
Language:
English
Keywords:
Pubs id:
1197080
Local pid:
pubs:1197080
Deposit date:
2022-02-25

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