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A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.

Abstract:

Foxp3(+) regulatory T (T reg) cells play a key role in controlling immune pathological re actions. Many develop their regulatory activity in the thymus, but there is also evidence for development of Foxp3(+) T reg cells from naive precursors in the periphery. Recent studies have shown that transforming growth factor (TGF)-beta can promote T reg cell development in culture, but little is known about the cellular and molecular mechanisms that mediate this pathway under more physiological condit...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20070590

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Journal:
Journal of experimental medicine
Volume:
204
Issue:
8
Pages:
1757-1764
Publication date:
2007-08-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
17911

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