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Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection.

Abstract:

Little is known of how a strong immune response in the lungs is regulated to minimize tissue injury during severe influenza A virus (IAV) infection. Here, using a model of lethal, high-pathogenicity IAV infection, we first show that Ly6C(hi)Ly6G(-) inflammatory monocytes, and not neutrophils, are the main infiltrate in lungs of WT mice. Mice devoid of iNKT cells (Jα18(-/-) mice) have increased levels of inflammatory monocytes, which correlated with increased lung injury and mortality (but not...

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Publication status:
Published

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Publisher copy:
10.1189/jlb.0411184

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Journal:
Journal of leukocyte biology
Volume:
91
Issue:
3
Pages:
357-368
Publication date:
2012-03-01
DOI:
EISSN:
1938-3673
ISSN:
0741-5400
Source identifiers:
193090

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