Journal article
Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection.
- Abstract:
-
Little is known of how a strong immune response in the lungs is regulated to minimize tissue injury during severe influenza A virus (IAV) infection. Here, using a model of lethal, high-pathogenicity IAV infection, we first show that Ly6C(hi)Ly6G(-) inflammatory monocytes, and not neutrophils, are the main infiltrate in lungs of WT mice. Mice devoid of iNKT cells (Jα18(-/-) mice) have increased levels of inflammatory monocytes, which correlated with increased lung injury and mortality (but not...
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- Publication status:
- Published
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- Publisher copy:
- 10.1189/jlb.0411184
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Authors
Bibliographic Details
- Journal:
- Journal of leukocyte biology
- Volume:
- 91
- Issue:
- 3
- Pages:
- 357-368
- Publication date:
- 2012-03-01
- DOI:
- EISSN:
-
1938-3673
- ISSN:
-
0741-5400
- Source identifiers:
-
193090
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:193090
- UUID:
-
uuid:515c4e35-197b-494f-8f15-1feb90349a26
- Local pid:
- pubs:193090
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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