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Development of therapeutic anti-JAGGED1 antibodies for cancer therapy

Abstract:

The role of Notch signaling and its ligand JAGGED1 (JAG1) in tumor biology have been firmly established, making them appealing therapeutic targets for cancer treatment. Here we report the development and characterization of human/rat-specific JAG1-neutralizing monoclonal antibodies. Epitope mapping identified their binding to the Notch receptor interaction site within the JAG1 Delta/Serrate/Lag2 domain, where E228D substitution prevented effective binding to the murine Jag1 orthologue. These ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/1535-7163.mct-18-1176

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Institution:
University of Oxford
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-7118-3401
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Institution:
University of Oxford
Department:
Biochemistry
Role:
Author
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Role:
Author
ORCID:
0000-0002-9668-9900
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Molecular Cancer Therapeutics Journal website
Volume:
18
Issue:
11
Pages:
2030-2042
Publication date:
2019-08-08
Acceptance date:
2019-08-02
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
Pmid:
31395687
Source identifiers:
1041788
Language:
English
Keywords:
Pubs id:
pubs:1041788
UUID:
uuid:51667f1b-2306-44af-90b3-38e23a5ae8bb
Local pid:
pubs:1041788
Deposit date:
2019-08-14

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