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Journal article

Bilateral functional connectivity of the basal ganglia in patients with Parkinson's disease and its modulation by dopaminergic treatment

Abstract:

Parkinson’s disease is characterised by excessive subcortical beta oscillations. However, little is known about the functional connectivity of the two basal ganglia across hemispheres and specifically the role beta plays in this. We recorded local field potentials from the subthalamic nucleus bilaterally in 23 subjects with Parkinson’s disease at rest, on and off medication. We found suppression of low beta power in response to levodopa (t22 = −4.4, p<0.001). There was significant coherenc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0082762

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
12
Pages:
ARTN e82762
Publication date:
2013-12-20
Acceptance date:
2013-11-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
445687
Language:
English
Keywords:
UUID:
uuid:518010b6-045e-4bc8-8a1c-cf5ac9090a4e
Local pid:
pubs:445687
Deposit date:
2014-02-08

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