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Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.

Abstract:

Interferon (IFN)-gamma was originally characterized as a pro-inflammatory cytokine with T helper type 1-inducing activity, but subsequent work has demonstrated that mice deficient in IFN-gamma or IFN-gamma receptor show exacerbated inflammatory responses and accelerated allograft rejection, suggesting that IFN-gamma also has important immunoregulatory functions. Here, we demonstrate that ex vivo IFN-gamma conditioning of CD4 T cells driven by allogeneic immature dendritic cells (DC) results i...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200838411

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Journal:
European journal of immunology
Volume:
38
Issue:
9
Pages:
2512-2527
Publication date:
2008-09-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
135984
Language:
English
Keywords:
Pubs id:
pubs:135984
UUID:
uuid:524eb3d4-ead7-4bc4-8213-ab4e422e90dd
Local pid:
pubs:135984
Deposit date:
2012-12-19

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