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Symmetry and structure in the POT family of proton coupled peptide transporters

Abstract:

The POT family of proton coupled oligopeptide transporters belong to the Major Facilitator Superfamily of secondary active transporters and are found widely distributed in bacterial, plant, fungal and animal genomes. POT transporters use the inwardly directed proton electrochemical gradient to drive the concentrative uptake of di- and tri-peptides across the cell membrane for metabolic assimilation. Mammalian members of the family, PepT1 and PepT2, are responsible for the uptake and retention...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3390/sym9060085

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Christ Church
Role:
Author
ORCID:
0000-0001-7432-2270
More from this funder
Funding agency for:
Newstead, S
Grant:
Investigator Award (102890/Z/13/Z
Publisher:
MDPI Publisher's website
Journal:
Symmetry Journal website
Volume:
9
Issue:
6
Article number:
85
Publication date:
2017-06-14
Acceptance date:
2017-06-08
DOI:
ISSN:
2073-8994
Source identifiers:
704519
Keywords:
Pubs id:
pubs:704519
UUID:
uuid:52921b34-7dac-4ed2-8eb6-09c1feec8626
Local pid:
pubs:704519
Deposit date:
2018-08-11

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