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Spatial structure and variability of the cardiac t-tubular system and its contribution to electrophysiological heterogeneity

Abstract:

Background: The cardiomyocyte cell membrane is composed of the surface membrane and a complex system of membrane invaginations, the t-tubules. In keeping with its role in synchronisation of electromechanical coupling, the t-tubular system is distinguished from the cell membrane by its ion channel composition. Variability of the architecture of the t-tubular system might modulate electrophysiological function at the cellular level. Light and electron microscopy-based methods were establishe...

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Oxford college:
Balliol College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:5294698e-0262-4e6d-bed5-d9c718da7577
Deposit date:
2016-11-15

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